021-51111890
购物车（）
sales@molnova.cn
[Sar9,Met(O2)11]-Substance P
CAS No. 110880-55-2
[Sar9,Met(O2)11]-Substance P ( —— )
产品货号. M29996 CAS No. 110880-55-2
Sar9, Met (O2)11-Substance P is a neurokinin-1 receptor agonist. It is an analog of the naturally occurring human neuropeptide Substance P, which can be found throughout the body, including in the airways of humans and many other species.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2066 | 有现货 |
|
| 10MG | ￥3722 | 有现货 |
|
| 25MG | ￥6070 | 有现货 |
|
| 50MG | ￥8352 | 有现货 |
|
| 100MG | ￥11304 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 5MG | ￥2066 | 有现货 |
|
| 10MG | ￥3722 | 有现货 |
|
| 25MG | ￥6070 | 有现货 |
|
| 50MG | ￥8352 | 有现货 |
|
| 100MG | ￥11304 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
生物学信息
-
产品名称[Sar9,Met(O2)11]-Substance P
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述Sar9, Met (O2)11-Substance P is a neurokinin-1 receptor agonist. It is an analog of the naturally occurring human neuropeptide Substance P, which can be found throughout the body, including in the airways of humans and many other species.
-
产品描述Sar9, Met (O2)11-Substance P is a neurokinin-1 receptor agonist. It is an analog of the naturally occurring human neuropeptide Substance P, which can be found throughout the body, including in the airways of humans and many other species.(In Vitro):[Sar9,Met(O2)11]-Substance P and septide (10-100?pmol per rat, i.c.v.) are equipotent in increasing mean arterial blood pressure (MAP) and heart rate (HR), yet they have dissimilar time-course. Both agonists increase dose-dependently face washing and sniffing while [Sar9,Met(O2)11]-Substance P is the sole to produce grooming.
-
同义词——
-
通路GPCR/G Protein
-
靶点Neurokinin Receptor
-
受体NK1 receptor
-
研究领域——
-
适应症——
化学信息
-
CAS Number110880-55-2
-
分子量1393.7
-
分子式C64H100N18O15S
-
纯度>98% (HPLC)
-
溶解度H2O : 50 mg/mL (35.88 mM; Need ultrasonic)
-
SMILES——
-
化学全称Sequence:Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-{Sar}-Leu-Met[O2]-NH2
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
Cellier E, et al. Characterization of central and peripheral effects of septide with the use of five tachykinin NK1 receptor antagonists in the rat. Br J Pharmacol. 1999 Jun;127(3):717-28.
产品手册
关联产品
-
QWF
Tripeptide substance P (SP) antagonist (IC50 = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching in mice in vivo.
-
Fosaprepitant dimegl...
Fosaprepitant dimeglumine(MK-0517) is a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting.
-
Substance P (1-9)
Substance P (1-9) is nonapeptide, which decreases the inactivation of substance P by the guinea-pig ileum and urinary bladder. Subtance P is responsible for a number of excitatory effects on both central and peripheral neurons.
